玛丽莎 L . Zallocchi博士
助理教授
玛丽莎's main research focus is to understand the relationship between specific transmembrane receptors, 整合蛋白, and the Usher proteins during inner ear development, 以及它们的作用机制.
研究的焦点
- Molecular basis of Usher syndrome during inner ear development.
- Role of 整合蛋白 during inner ear development and their involvement in Usher protein function
- Identifiation of small molecule therapies to protect against acquired hearing loss
部门
生物医学科学
位置
助理教授
文章
- 听力的研究
张, 天洋, Xu, Zhenhang; Zheng, Danya; Wang, Xuechun; He, Jinghun; 张, Luping; Zallocchi,玛丽莎 Pediatric auditory neuropathy spectrum disorder is a particular type of hearing loss caused by abnormal sound transmission from the cochlea to the brain. It is due to defective peripheral synaptic function or improper neuronal conduction. 使用三重奏全外显子组测序, we have identified novel biallelic variants in the PLEC gene in three individuals with profound deafness from two unrelated families. 在他们中间, one pediatric patient diagnosed with auditory neuropathy spectrum disorder had a good cochlear implantation outcome. The other two adult patients were diagnosed with non-syndromic hearing loss. Studies in mice and zebrafish confirmed that plectin is developmentally expressed in the inner ear. 此外, plectin's knockdown resulted in a reduction of synaptic mitochondrial potential and loss of ribbon synapses, reinforcing the idea of a role for plectin in neuronal transmission. 完全, 这里给出的结果是, point to a new unconventional role for plectin in the inner ear. Contrary to the well-characterized association of plectin to skin and muscle diseases, we found that specific plectin mutations can result in hearing loss with no other clinical manifestations. This is important because 1) it provides evidence of plectin's involvement in inner ear function and 2) it will help clinicians at the time of diagnosis and treatment
436 2023 - European Journal of Medicinal Chemistry
Santanu Hati *, 玛丽莎Zallocchi *, 罗伯特·黑兹利特, Yuju李, Sarath Vijayakumar, Jaeki敏, Zoran Rankovic, 桑德尔风之子, 剑左. AZD5438-PROTAC: A Selective CDK2 Degrader that Protects Against Cisplatin- and Noise-Induced Hearing Loss. In press in European Journal of Medicinal Chemistry (2021). *平等的贡献
226 2021 - 青:洞察力
玛丽莎Zallocchi , Zallocchi米, Hati S, 徐Z, Hausman W, 刘H, 他维Z, 左J. Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss. 江森自控的洞察力. 2021 3月8日;6(5):141561. doi: 10.1172 /青.洞察力.141561. 2021 - 青:洞察力
玛丽莎Zallocchi , Zallocchi米, Hati S, 徐Z, Hausman W, 刘H, 他维Z, 左J. Characterization of quinoxaline derivatives for protection against iatrogenic-induced hearing loss. 青:洞察力，出版中. 2021 - 科学的进步
“BRAF inhibition protects against hearing loss in mice” 2020. Ingersoll米, 马洛依E, 施法者L, 荷兰E, 徐Z, Zallocchi米, 制革匠D, 刘H, 他维, 分钟J, 陈老师, 左J, Teitz T. Sci. 阿德. 6 (49): eabd0561. 2020 - 科学的进步
马修一个. 艾玛·英格索尔. 劳伦·E·马洛伊. 伊娃·M·卡斯特. 荷兰, Zhenhang徐, 玛丽莎Zallocchi, 杜安制革匠, Jaeki敏, Taosheng陈, 剑左, 和塔尔·泰兹. . Anti-Cancer BRAF Inhibitors Protect Against Cisplatin- and Noise-induced Hearing Loss. Sci副词. (2020) 6 (49): eabd0561. 2020 - Sci代表
Rocha-Sanchez S, Fuson O, Tarang S, Goodman L, Pyakurel U, 刘H, 他维Z, and 玛丽莎Zallocchi. Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage. Sci. 代表. (2018) 8(1):15119.
8 2018 - J. 细胞科学.
Goodman L and Zallocchi米 Integrin 8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cell. J. 细胞科学，2017,30(21):3698-3712. 2017 - 听力的研究
Meehan DT, Delimont D, Dufek B, Zallocchi米, Phillips G, Gratton MA, Cosgrove D. Endothelin-1 mediated induction of extracellular matrix genes in strial marginal cells underlies strial pathology in Alport mice. 听到Res. (2016) 341:100-108.
341, p. 100-108 2016 - J. 细胞生物学
Ogun O和Zallocchi米. Clarin-1 acts as a modulator of mechanotransduction activity and presynaptic ribbon assembly. J. 细胞生物. (2014) 207, 375-391. 2014 - 《皇冠体育博彩》
Delimont D, Dufek B, Meehan D, Zallocchi米, Gratton M, Phillips G and Cosgrove D. Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. 《皇冠体育博彩》 (2014) e99083.
9 2014 - 玛丽莎Zallocchi *, Pezhman Salehi*, Sarath Vijayakumar, Madeleine Urbanek, Kimberlee P. 吉芬, Yuju李, Santanu Hati, 剑左 In silico transcriptomics identifies FDA-approved drugs and biological pathways for protection against cisplatin-induced hearing loss. 在审查中，eLife. *同等贡献-0001
联邦
The goal of this proposal is to characterize natural products to protect hair cells from aminoglycoside-induced hearing loss.
其他
To characterize the regulation of Itga8-Pcdh15 complex during inner ear development
Study the role of integrin alpha-8 and protocadherin-15 complex during vestibular hair cell maturation.